HPLC Determination of Valproic Acid as Bromophenacyl Ester in Blood Plasma
โ Scribed by M. D. Rukhadze; M. V. Gonashvili; A. N. Zirakishvili; N. V. Okudzhava
- Book ID
- 110340510
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 78 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0091-150X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A sensitive and specific method for the determination of valproic acid in plasma has been developed. After the proteins in the plasma have been precipitated with a saturated solution of ammonium sulfate in 1 N HCI, the valproic acid, together with the internal standard, is extracted from the plasma
Valproic acid (di-n-propylacetic acid) is the free acid form of the drug'm-aketed under the names of Epilim, Sodium Valproate, and Depakine. Although valproic acid has been used for a number of years as an anti-epileptic drug, littIe has-been published on analytical methods and plasma levels I\*\*.