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How the epigenome contributes to the development of psychiatric disorders

✍ Scribed by Timothy W. Bredy; Yi E. Sun; Michael S. Kobor

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
128 KB
Volume
52
Category
Article
ISSN
0012-1630

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Epigenetics commonly refers to the developmental process by which cellular traits are established and inherited without a change in DNA sequence. These mechanisms of cellular memory also orchestrate gene expression in the adult brain and recent evidence suggests that the β€œepigenome” represents a critical interface between environmental signals, activation, repression and maintenance of genomic responses, and persistent behavior. We here review the current state of knowledge regarding the contribution of the epigenome toward the development of psychiatric disorders. Β© 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 331–342, 2010.

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