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How do peptides associate with MHC class I molecules?

✍ Scribed by Tim Elbort


Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
379 KB
Volume
12
Category
Article
ISSN
0167-5699

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Tapasin edits peptides on MHC class I mo
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## Abstract The endoplasmic reticulum (ER) protein tapasin is essential for the loading of high‐affinity peptides onto MHC class I molecules. It mediates peptide editing, __i.e.__ the binding of peptides of successively higher affinity until class I molecules pass ER quality control and exit to the