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Supply and transport of peptides presented by class I MHC molecules

✍ Scribed by Jonathan C Howard

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
803 KB
Volume
7
Category
Article
ISSN
0952-7915

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## Abstract The endoplasmic reticulum (ER) protein tapasin is essential for the loading of high‐affinity peptides onto MHC class I molecules. It mediates peptide editing, __i.e.__ the binding of peptides of successively higher affinity until class I molecules pass ER quality control and exit to the