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How does TAP associate with MHC class I molecules?

✍ Scribed by Tim Elliott


Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
354 KB
Volume
18
Category
Article
ISSN
0167-5699

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MHC class I molecules assemble within the endoplasmic reticulum (ER) in complexes that include g 2-microglobulin ( g 2 m), the transporter associated with antigen processing (TAP) and several additional chaperones. Release of class I complexes from the ER is thought to require the binding of an appr