Hormone dependence of breast cancer cells and the effects of tamoxifen and estrogen:31P NMR studies
✍ Scribed by Jesús Ruiz-Cabello; Kirsten Berghmans; Ofer Kaplan; Marc E. Lippman; Robert Clarke; Jack S. Cohen
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 832 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Choline metabolism in breast cancer cells and tumors has been investigated by multinuclear NMR in order to provide the biochemical basis for the presence of high phosphocholine in breast carcinoma relative to benign breast tumors and normal breast tissue. Choline was found to be transported into MCF
## Abstract Estrogen receptor (ER)‐positive acquired tamoxifen‐resistant (TAM‐R) MCF‐7 breast cancer cell lines exhibit epidermal growth factor receptor (EGFR) expression/signaling and are growth‐inhibited by gefitinib (IRESSA). We examined the effect of gefitinib on ER‐positive TAM‐R and ER‐negati