The translocatable receptors categorized as functional receptors were quantitated in a cross-incubation study of breast cancer nuclei with receptor-rich uterine cytosol. Data demonstrated that tumors that contained cytosolic estrogen receptor (ER) but had translocation defect might not be hormone de
Molecular action of the estrogen receptor and hormone dependency in breast cancer
โ Scribed by Hirotaka Iwase
- Publisher
- Springer Japan
- Year
- 2003
- Tongue
- English
- Weight
- 931 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1340-6868
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Recent evidence suggests that the progression to hormone resistance in some breast tumors is due to mutations in the estrogen receptor (ER). Various types of ER variants have been found in breast cancer biopsies and breast cancer cell lines. The ER variants include dominant-positive receptors that a
## Abstract The importance of androgens and androgen receptors (AR) in primary prostate cancer is well established. Metastatic disease is usually treated with some form of androgen ablation, which is effective for a limited amount of time. The role of AR in prostate cancers that recur despite andro
## Abstract Resistance to hormonal therapy is often a problem in the treatment of breast cancer patients. It has been suggested that resistance could be explained by altered nuclear hormone receptor or coregulator levels or inappropriately increased agonist activity of selective estrogen receptor m