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Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

✍ Scribed by Gruis, Nelleke A.; van der Velden, Pieter A.; Sandkuijl, Lodewijk A.; Prins, Duncan E.; Weaver-Feldhaus, Jane; Kamb, Alexander; Bergman, Wilma; Frants, Rune R.

Book ID: 109916476
Publisher: Nature Publishing Group
Year: 1995
Tongue: English
Weight: 310 KB
Volume: 10
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng0795-351

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## Abstract Germline mutations in the __CDKN2A__ gene have been shown to predispose individuals to cutaneous malignant melanoma. Here, we describe three melanoma‐prone families and one isolated patient affected by multiple melanoma who carried a tandem germline mutation of __CDKN2A__ at the nucleot