Two p16 (CDKN2A) germline mutations in 30 Israeli melanoma families
β Scribed by Yakobson, Emanuel; Shemesh, Pnina; Azizi, Esther; Winkler, Eyal; Lassam, Norman; Hogg, David; Brookes, Sharon; Peters, Gordon; Lotem, Michal; Zlotogorski, Abraham
- Book ID
- 110024998
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 256 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1018-4813
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Germline CDKN2A mutations have been observed in approximately 20 percent of familial melanoma kindreds from North America, Europe and Australasia. There is also an increased risk of pancreatic cancer in a subset of families with mutations, however, the precise relationship between the CDKN2A gene an
The cell cycle is composed of a series of steps that can be negatively or positively regulated by various factors. A group of low-molecular-weight proteins have recently been identified that specifically inhibit the function of cyclin-dependent kinases in mammalian cells. Inactivation of the CDKNZA