Cytogenetic analyses were performed on 223 breast carcinomas, of which 60% contained homogeneously staining regions (hsr), an intrachromosomal cytogenetic feature of gene amplification. The precise hsr localization could be determined for 123 hsr from 72 cases. The juxtacentromeric region of chromos
Homogeneously staining regions in 223 breast carcinomas: cytogenetic and clinicopathological correlations
β Scribed by Dutrillaux, B; Bernardino, J; Gerbault-Seureau, M; Zafrani, B; Dericke, Y; Boudou, E; Magdelenat, H
- Book ID
- 109838663
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 789 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Cytogenetic studies on fresh human breast cancers revealed that homogeneously staining regions (HSRs), which are assumed t o represent DNA amplification, are observed in almost half of the cases. To search for a possible relationship between HSRs and proto-oncogene amplification, I 6 proto-oncogenes
## Abstract A modified comparative genomic hybridization (mCGH) technique was applied to a series of 17 primary breast carcinomas in which cytogenetic study (CG) demonstrated the presence of homogeneously staining region(s), suggesting the occurrence of DNA amplification. mCGH demonstrated recurren
A modified comparative genomic hybridization (mCGH) technique was used t o identify and map amplified DNA sequences in six homogeneously staining regions (hsr) from three primary breast carcinomas. Five different chromosomal regions and bands were identified as sites of amplification: 8p I, I7q2 I.