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Homodimerization of hyaluronan and heparan sulfate derivatives by olefin metathesis reaction

✍ Scribed by Shyam M Rele; Suri S Iyer; Elliot L Chaikof

Book ID
104252593
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
98 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Hyaluronan and heparan sulfate disaccharides of the type b-D-glucuronic acid-(13)-N-acetyl-b-D-glucosamine and a-L-iduronic acid-( 14)-N-acetyl-b-D-glucosamine, respectively, with an n-pentenyl group at the reducing end have been synthesized. Homodimerization of these derivatives using Grubbs catalyst furnished dimerized disaccharides separated by a C 8 spacer arm.

πŸ“œ SIMILAR VOLUMES

Facile Preparation of Divalent Sialoside
Facile Preparation of Divalent Sialoside Derivatives by Olefin Metathesis Reaction
✍ Zhonghong Gan; RenΓ© Roy πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 128 KB

Olefin metathesis catalyzed by RuCl 2 (CHPh)(PCy 3 ) 2 (1) has been used to synthesize homodimers of O-and S-alkenyl a-sialoside derivatives. The reactions afforded reasonable to good yields under mild reaction conditions. Trans-geometrical isomers were preferred in all cases.