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Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

โœ Scribed by Gavin, Marc A.; Clarke, Sally R.; Negrou, Ella; Gallegos, Alena; Rudensky, Alexander


Book ID
109923487
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
439 KB
Volume
3
Category
Article
ISSN
1529-2908

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We have further characterized the in vitro phenotype and function of anergic and suppressive CD4(+)25(+) T cells. Following TCR ligation, DO.11.10 CD4(+)25(+) T cells suppress the activation of OT-1 CD8(+)25(-) T cells in an antigen nonspecific manner. Although suppression was seen when using a mixt