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Hole Mobility in DNA: Effects of Static and Dynamic Structural Fluctuations

✍ Scribed by Ferdinand C. Grozema; Laurens D. A. Siebbeles; Yuri A. Berlin; Mark A. Ratner

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
85 KB
Volume
3
Category
Article
ISSN
1439-4235

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Oxidative damage to DNA by ionizing radiation, carcinogenic agents, and photosensitizers occurs predominately at guanine (G) bases, [1, 2] a result which can be rationalized by the hierarchy of in vitro oxidation potentials of the isolated nucleobases (G < A ( C,T). [3] Strand cleavage reactions, in