Oxidative damage to DNA by ionizing radiation, carcinogenic agents, and photosensitizers occurs predominately at guanine (G) bases, [1, 2] a result which can be rationalized by the hierarchy of in vitro oxidation potentials of the isolated nucleobases (G < A ( C,T). [3] Strand cleavage reactions, in
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Dynamics of Hole Trapping by G, GG, and GGG in DNA
✍ Scribed by William B. Davis; Izabela Naydenova; Reinhard Haselsberger; Alexander Ogrodnik; Bernd Giese; Maria E. Michel-Beyerle
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 128 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0044-8249
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## Abstract RNA and DNA molecules experience motions on a wide range of time scales, ranging from rapid localized motions to much slower collective motions of entire helical domains. The many functions of RNA in biology very often require this molecule to change its conformation in response to biol