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HLA—DRB1 genes and disease severity in rheumatoid arthritis

✍ Scribed by John D. Reveille; Graciela S. Alarcón; Sarah E. Fowler; Stanley R. Pillemer; Rosemarie Neuner; Daniel O. Clegg; Isis S. Mikhail; David E. Trentham; James C. C. Leisen; Gilbert Bluhm; Sheldon M. Cooper; Howard Duncan; Marilyn Tuttleman; Stephen P. Heyse; John T. Sharp; Barbara Tilley; For the MIRA trial group

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 581 KB
Volume: 39
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780391105

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## Abstract ## Objective The HLA–DRB1 “shared epitope” (SE) genotypes are associated with rheumatoid arthritis (RA), but it remains controversial whether the association is with incidence, severity, or both, whether there are associations in seronegative patients, and whether different DRB1 allele