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A new classification of HLA–DRB1 alleles differentiates predisposing and protective alleles for rheumatoid arthritis structural severity

✍ Scribed by Pierre-Antoine Gourraud; Jean-Frédéric Boyer; Thomas Barnetche; Michel Abbal; Anne Cambon-Thomsen; Alain Cantagrel; Arnaud Constantin


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
77 KB
Volume
54
Category
Article
ISSN
0004-3591

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The HLA–DRB1 shared epitope alleles are
✍ Annette H. M. van der Helm-van Mil; Kirsten N. Verpoort; Ferdinand C. Breedveld; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 59 KB 👁 1 views

## Abstract ## Objective The shared epitope (SE)–containing HLA–DRB1 alleles represent the most significant genetic risk factor for rheumatoid arthritis (RA). Recent studies indicate that the SE alleles are associated with only RA that is characterized by the presence of anti–cyclic citrullinated