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Relationship among the HLA-DRB1 shared epitope, smoking, and rheumatoid factor production in rheumatoid arthritis

✍ Scribed by Mattey, Derek L. ;Dawes, Peter T. ;Clarke, Sheila ;Fisher, June ;Brownfield, Ann ;Thomson, Wendy ;Haajeer, Ali H. ;Ollier, William E. R.


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
66 KB
Volume
47
Category
Article
ISSN
0004-3591

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Objective. To investigate whether interactions between tumor necrosis factor (TNF) microsatellite polymorphisms and the HLA-DRB1 shared epitope (SE) are associated with disease severity in rheumatoid arthritis (RA), and to determine if such associations are the same in male and female patients. Met