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HLA genotypes in familial Hodgkin's disease. Excess of HLA identical affected sibs

โœ Scribed by J. Hors; G. Steinberg; J.M. Andrieu; C. Jacquillat; M. Minev; J. Messerschmitt; G. Malinvaud; F. Fumeron; J. Dausset; J. Bernard


Book ID
113146473
Publisher
Elsevier Science
Year
1980
Weight
421 KB
Volume
16
Category
Article
ISSN
0014-2964

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## Abstract In a study of 13 families prone to Hodgkin's disease, the probands showed significant excesses of the HLA antigens Bw35 (7 cases) and Bw37 (3 cases). Although based on a small number of patients, the results suggest that immunogenetic mechanisms account at least partly for the familial

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## Abstract A familial aggregate of seven cases of Hodgkin's disease (HD) has been investigated by HLA typing. Over 600 people in the immediate population (__i.e__. about half) have been HLA typed and haplotypes have been obtained for 95% of them. It was expected that the cases would share a partic

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The occurrence of multiple sclerosis (MS) in several members of families has been observed in 4.8% of 105 MS patients from a limited epidemiological area of Rostock. Typing of the HLA antigens in 4 affected sib-pairs showed two identical HLA haplotypes in 3 of the pairs: 1 pair shared one haplotype.