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Family studies in multiple sclerosis: HLA haplotypes of affected sib-pairs

โœ Scribed by H. J. Mayer-Rienecker; S. Wegener; B. Hitzschke

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
224 KB
Volume
234
Category
Article
ISSN
1433-8491

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โœฆ Synopsis

The occurrence of multiple sclerosis (MS) in several members of families has been observed in 4.8% of 105 MS patients from a limited epidemiological area of Rostock. Typing of the HLA antigens in 4 affected sib-pairs showed two identical HLA haplotypes in 3 of the pairs: 1 pair shared one haplotype. These findings point to a dominant mode of inheritance of the disease susceptibility gene together with the HLA haplotype. The assessment of family studies in MS is discussed.

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