HLA-DQ6-mediated protection in IDDM
β Scribed by Carani B Sanjeevi
- Book ID
- 117415976
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 645 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0198-8859
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Key words: restriction fragment length polymorphism (RFLP), insulin gene 5' flanking polymorphism (5' FP), insulm gene 6.0-kb probe, Southern blotting, HLA-DBP band patterns, HLA-DQP band patterns, HLA-DR subtypes I NTROD UCTl ON A principal aim of the insulin-dependent diabetes mellitus (IDDM) comp
The HLA class &related susceptibility to type I insulin-dependent diabetes mellitus (IDDM) is examined in 94 multiplex families sorted by the presence or absence of a DR4+ haplotype in at least one diabetic family member. The families with DR4+ haplotypes are then sorted by the presence or absence o