Linkage analysis of HLA DR antigen as well as DR and DQ restriction fragment length polymorphism (RFLP) data using the LIPED computer program and various three-allele disease locus models showed very close linkage to an insulindependent diabetes mellitus (1DDM)-susceptibility locus. RFLP data alone
Restriction fragment polymorphisms of the HLA-DR, HLA-DQ, and insulin gene regions in IDDM: The GAW5 data
✍ Scribed by N. J. Cox; K. J. Gogolin; V. J. Horvath; D. F. Barker; E. Wright; T. Tran; M. H. Skolnick; B. O. Boehm; K. Fehsel; J. Bertrams; T. W. Hodge; R. T. Acton; J. McGill; S. C. Elbein; M. A. Permutt; C. de Préval; P. Avoustin; A. Cambon-Thomsen; D. M. Robinson; S. L. Holbeck; G. T. Nepom; P. M. Schneider; C. Rittner; H. Toyoda; J. I. Rotter; Dr. R. Spielman
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 418 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0741-0395
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✦ Synopsis
Key words: restriction fragment length polymorphism (RFLP), insulin gene 5' flanking polymorphism (5' FP), insulm gene 6.0-kb probe, Southern blotting, HLA-DBP band patterns, HLA-DQP band patterns, HLA-DR subtypes I NTROD UCTl ON A principal aim of the insulin-dependent diabetes mellitus (IDDM) component of Genetic Analysis Workshop 5 (GAWS) was to study restriction fragment length
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