HLA DQβ3.2 identifies subtypes of DR4 + haplotypes permissive for IDDM

✍ Scribed by David M. Robinson; Susan Holbeck; Jerry Palmer; Gerald T. Nepom

• Book ID: 102224670
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 361 KB
• Volume: 6
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370060128

✦ Synopsis

The HLA class &related susceptibility to type I insulin-dependent diabetes mellitus (IDDM) is examined in 94 multiplex families sorted by the presence or absence of a DR4+ haplotype in at least one diabetic family member. The families with DR4+ haplotypes are then sorted by the presence or absence of a DR4-linked DQP3.2 allele. Further analysis assumes each multiplex family to represent a single diabetic genetic event and identifies the HLA class II haplotype(s) present in all affected members. The DQP3.2 allele is present in over 95 % of the multiplex families where DR4+ haplotypes segregate with IDDM, implying a major permissive role in determining susceptibility to IDDM.