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HLA-C genes and susceptibility to type 1 autoimmune hepatitis

✍ Scribed by MD Strettell; LJ Thomson; PT Donaldson; M Bunce; CM O'Neill; R Williams

Book ID
118686714
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
188 KB
Volume
26
Category
Article
ISSN
0270-9139

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HLA-C genes and susceptibility to type 1
HLA-C genes and susceptibility to type 1 autoimmune hepatitis
✍ M D Strettell; L J Thomson; P T Donaldson; M Bunce; C M O'Neill; R Williams πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 189 KB

Susceptibility to autoimmune hepatitis (AIH) is associated with the HLA A1-B8-DR3 haplotype, DR4 antigen, and, more specifically, the HLA DRB3\*0101, DRB1\*0301, and DRB1\*0401 alleles. Few investigators, however, have examined the HLA C locus in AIH, which warrants detailed study in view of its rec

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Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1\*0301 and DRB1\*0401. The gene encoding cytotoxic T-lymphocyte antigen-4 (CTLA-4) on chromosome 2q33 may also influence autoimmuni