Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
β Scribed by Nejentsev, Sergey; Howson, Joanna M. M.; Walker, Neil M.; Szeszko, Jeffrey; Field, Sarah F.; Stevens, Helen E.; Reynolds, Pamela; Hardy, Matthew; King, Erna; Masters, Jennifer
- Book ID
- 109897106
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 588 KB
- Volume
- 450
- Category
- Article
- ISSN
- 0028-0836
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract In this report, we present evidence that the HLA class II DPB1 locus (or a locus with alleles in linkage disequilibrium with DPB1) contributes to Type I diabetes (IDDM) susceptibility in addition to the contribution of the HLA DR and DQ loci. The marker association segregation chiβsquar
HLA-A3 and HLA-B7 class-I genes are differentially regulated in human T lymphoma Jurkat cells, at the trancriptional level, the expression of the HLA-B7 gene being selectively increased following a, p or y interferon (IFN) treatment. Using a series of hybrid CAT constructs, associating HLA-A3 and HL