✦ LIBER ✦

HIV-1 protease inhibitors containing a novel C2 symmetrical hydroxyalkylgem-diamino core structure

✍ Scribed by MARASTONI, MAURO ;SALVADORI, SEVERO ;BORTOLOTTI, FABRIZIO ;TOMATIS, ROBERTO

Book ID: 110893587
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 577 KB
Volume: 49
Category: Article
ISSN: 1397-002X
DOI: 10.1111/j.1399-3011.1997.tb01161.x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Stereocontrolled synthesis of pseudo C2-

Stereocontrolled synthesis of pseudo C2-symmetric 1,3-diamino-2-propanol core units of HIV protease inhibitors

✍ Alessandro Dondoni; Daniela Perrone 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 228 KB

The synthesis of the pseudo C2-symmetric dibenzyldiamino alcohol (S,S)-I and the two meso stereoisomers la and lb (R = PhCH2) is described by stereocontrolled benzylmagnesium chloride addition to the nitrones 3 derived from chiral ~-amino-c~-hydroxy aldehydes 2 that in turn were obtained from phenyl

A diastereoselective synthesis of pseudo

A diastereoselective synthesis of pseudo-C2 -symmetric 1,3-diamino-2-propanols as core units in HIV protease inhibitors

✍ Steven J. Wittenberger; William R. Baker; B.Gregory Donner 📂 Article 📅 1993 🏛 Elsevier Science 🌐 French ⚖ 849 KB

ChemInform Abstract: Stereocontrolled Sy

ChemInform Abstract: Stereocontrolled Synthesis of Pseudo C2-Symmetric 1,3-Diamino-2- propanol Core Units of HIV Protease Inhibitors.

✍ A. DONDONI; D. PERRONE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

ChemInform Abstract: A Novel and Facile

ChemInform Abstract: A Novel and Facile Synthesis of C2-Symmetric HIV — Protease Inhibitors.

✍ G. Vidyasagar Reddy; D. S. Iyengar 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Structure-Guided Design of C2-Symmetric

Structure-Guided Design of C2-Symmetric HIV-1 Protease Inhibitors Based on a Pyrrolidine Scaffold†

✍ Blum, Andreas; Böttcher, Jark; Heine, Andreas; Klebe, Gerhard; Diederich, Wibke 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 712 KB

Potent HIV protease inhibitors containin

Potent HIV protease inhibitors containing a novel (2-phenylsulfanyl-1-hydroxyethyl)amide isostere

✍ L. Rocheblave; G. Priem; C. De Michelis; J.L. Kraus 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 187 KB

Based on the concept of bioisosterism, we report the design and synthesis of new protease inhibitors. These new compounds incorporate in their backbone the synthon 2-N-Acyl-2-Phenylsulfanyl-1-Hydroxyethyl (I) which confers on the resulting compounds both in vitro activity on MT4 infected c~lls and H