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A diastereoselective synthesis of pseudo-C2 -symmetric 1,3-diamino-2-propanols as core units in HIV protease inhibitors

✍ Scribed by Steven J. Wittenberger; William R. Baker; B.Gregory Donner


Book ID
108371570
Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
849 KB
Volume
49
Category
Article
ISSN
0040-4020

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Stereocontrolled synthesis of pseudo C2-
✍ Alessandro Dondoni; Daniela Perrone πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 228 KB

The synthesis of the pseudo C2-symmetric dibenzyldiamino alcohol (S,S)-I and the two meso stereoisomers la and lb (R = PhCH2) is described by stereocontrolled benzylmagnesium chloride addition to the nitrones 3 derived from chiral ~-amino-c~-hydroxy aldehydes 2 that in turn were obtained from phenyl