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Concise and Stereocontrolled Synthesis of Pseudo- C 2 -symmetric Diamino Alcohols and Triamines for Use in HIV Protease Inhibitors

โœ Scribed by Bernardi, Luca; Bonini, Bianca F.; Dessole, Gabriella; Fochi, Mariafrancesca; Comes-Franchini, Mauro; Gavioli, Silvia; Ricci, Alfredo; Varchi, Greta


Book ID
120410074
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
165 KB
Volume
68
Category
Article
ISSN
0022-3263

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Stereocontrolled synthesis of pseudo C2-
โœ Alessandro Dondoni; Daniela Perrone ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 228 KB

The synthesis of the pseudo C2-symmetric dibenzyldiamino alcohol (S,S)-I and the two meso stereoisomers la and lb (R = PhCH2) is described by stereocontrolled benzylmagnesium chloride addition to the nitrones 3 derived from chiral ~-amino-c~-hydroxy aldehydes 2 that in turn were obtained from phenyl