✦ LIBER ✦

Potent HIV protease inhibitors containing a novel (2-phenylsulfanyl-1-hydroxyethyl)amide isostere

✍ Scribed by L. Rocheblave; G. Priem; C. De Michelis; J.L. Kraus

Book ID: 104261490
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 187 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00707-8

No coin nor oath required. For personal study only.

✦ Synopsis

Based on the concept of bioisosterism, we report the design and synthesis of new protease inhibitors. These new compounds incorporate in their backbone the synthon 2-N-Acyl-2-Phenylsulfanyl-1-Hydroxyethyl (I) which confers on the resulting compounds both in vitro activity on MT4 infected c~lls and HIV-I protease inhibition properties.

📜 SIMILAR VOLUMES

Synthesis and pharmacokinetics of potent

Synthesis and pharmacokinetics of potent carbamate HIV-1 protease inhibitors containing novel high affinity hydroxyethylamine isosteres

✍ William J. Hornback; John E. Munroe; Timothy A. Shepherd; Steve D. Hatch; Mark A 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 279 KB

Ly316340: A potent HIV-1 protease inhibi

Ly316340: A potent HIV-1 protease inhibitor containing a high affinity octahydrothienopyridine hydroxyethylamine isostere

✍ John E. Munroe; William J. Hornback; Jack B. Campbell; Michael A. Ouellette; Ste 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 320 KB

ChemInform Abstract: Synthesis of Irreve

ChemInform Abstract: Synthesis of Irreversible HIV-1 Protease Inhibitors Containing Sulfonamide and Sulfone as Amide Bond Isosteres.

✍ N. CHOY; H. CHOI; W. H. JUNG; C. R. KIM; H. YOON; S. C. KIM; T. G. LEE; J. S. KO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 2 views

Potent, orally bioavailable HIV-1 protea

Potent, orally bioavailable HIV-1 protease inhibitors containing noncoded D-amino acids

✍ John E. Munroe; Timothy A. Shepherd; Louis N. Jungheim; William J. Hornback; Ste 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 310 KB

Novel Spirocyclic Pyrrolidones as P2/P1

Novel Spirocyclic Pyrrolidones as P2/P1 Mimetics in Potent Inhibitors of HIV-1 Protease.

✍ Wieslaw M. Kazmierski; Eric Furfine; Andrew Spaltenstein; Lois L. Wright 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 138 KB 👁 2 views

(Hydroxyethyl) sulfonamide HIV-1 Proteas

(Hydroxyethyl) sulfonamide HIV-1 Protease inhibitors: Identification of the 2-methylbenzoyl moiety at P-2

✍ John N. Freskos; Deborah E. Bertenshaw; Daniel P. Getman; Robert M. Heintz; Bren 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 260 KB

Abstrf, et : We have discovered a potent low molecular weight series of HIV-1 Protease inhibitors incorporating the (R)-(hydroxyethyl) sulfonamide isostere. The human immunodeficiency virus type-1 (HIV-1), the causative agent of AIDS, encodes for a unique aspartyl protease, which has been shown to