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Synthesis and pharmacokinetics of potent carbamate HIV-1 protease inhibitors containing novel high affinity hydroxyethylamine isosteres

โœ Scribed by William J. Hornback; John E. Munroe; Timothy A. Shepherd; Steve D. Hatch; Mark A. Muesing; MaryAnn Wiskerchen; Joseph M. Colacino; Angela J. Baxter; Kenneth S. Su; Kristina M. Campanale


Book ID
108038922
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
279 KB
Volume
5
Category
Article
ISSN
0960-894X

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Solid phase synthesis of hydroxyethylami
โœ Paul F. Alewood; Ross I. Brinkworth; Robert J. Dancer; Bronwyn Garnham; Alun Jon ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 274 KB

A protocol has been kvelopedjiu rht generation qf hylroxyehyhnine peptide bond isosmes in a poipcr- sqprted synthesis. This has been used to produce the potent HlV-I Protease inhibitor JG345 rqidiy and in good yield. Protease inhibitors have outstanding potential as therapeutic agentst. Recently it