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HIV-1-infected macrophages induce astrogliosis by SDF-1α and matrix metalloproteinases

✍ Scribed by Mika Okamoto; Xin Wang; Masanori Baba

Book ID
116291377
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
257 KB
Volume
336
Category
Article
ISSN
0006-291X

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## Abstract Stromal cell‐derived factor 1 alpha (SDF‐1α) and its receptor CXCR4 play important roles in the pathogenesis of human immunodeficiency virus type one (HIV‐1)‐associated dementia (HAD) by serving as a HIV‐1 co‐receptor and affecting cell migration, virus‐mediated neurotoxicity, and neuro