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Efficient inhibition of SDF-1α-mediated chemotaxis and HIV-1 infection by novel CXCR4 antagonists

✍ Scribed by Yuki Iwasaki; Hirofumi Akari; Tsutomu Murakami; Sei Kumakura; Md. Zahidunnabi Dewan; Mikiro Yanaka; Naoki Yamamoto

Book ID
108586421
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
496 KB
Volume
100
Category
Article
ISSN
1347-9032

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## Abstract Gliomas take a number of different genetic routes in the progression to glioblastoma multiforme, a highly invasive variant that is mostly unresponsive to current therapies. The α‐chemokine stromal cell‐derived factor (SDF)‐1α binds to the seven transmembrane G‐protein‐coupled CXCR‐4 rec