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Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1

✍ Scribed by K. Gotoh; M. Yoshimori; K. Kanbara; H. Tamamura; T. Kanamoto; K. Mochizuki; N. Fujii; H. Nakashima


Publisher
Springer
Year
2001
Tongue
English
Weight
219 KB
Volume
7
Category
Article
ISSN
1341-321X

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## Abstract Within the brain, HIV‐1 targets the microglia and astrocytes. Previous studies have reported that viral entry into astrocytes is independent of CD4, in contrast to microglia. We aimed to determine whether chemokine receptors play a role in mediating CD4‐independent HIV‐1 entry into astr