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Efficient gene transfer mediated by HIV-1-based defective lentivector and inhibition of HIV-1 replication

โœ Scribed by Ling-bing Zeng; Lin-bai Ye; Yuanan Lu


Book ID
107635905
Publisher
SP Wuhan Institute of Virology, CAS
Year
2007
Tongue
English
Weight
390 KB
Volume
22
Category
Article
ISSN
1674-0769

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HIV-1-based defective lentiviral vectors
โœ Lingbing Zeng; Vicente Planelles; Ziye Sui; Suzanne Gartner; Sanjay B. Maggirwar ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 302 KB

Background Human monocytes play an important role in mediating human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS), and monocytes-derived macrophages (MDM) represent a major viral reservoir within the brain and other target organs. Current gene transduction of M