✦ LIBER ✦

Histopathological study on N-ethyl-N′-nitro-N-nitrosoguanidine-induced colon cancer in dogs

✍ Scribed by Toshiki Kamano; Hiroshi Kishino; Ken Mizukami; Noboru Azuma; Junji Tamura; Atsuo Katami; Tsutomu Kidokoro

Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 609 KB
Volume: 32
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910320219

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We prepared a suppository containing 50 mg of N‐ethyl‐N′‐nitro‐N‐nitrosoguanidine (ENNG), and successfully produced experimental colon cancer with good reproducibility by continuous intrarectal insertion of one or two suppositories per day in dogs. The tumors were very similar to human colon cancers, macroscopically and histologically. In one of three dogs subjected to histopathological study, metastases to the lymph nodes, lung, liver and kidney were observed. This animal model produced by a simple procedure will be helpful in investigating treatment of rectal cancer.

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