Effects of bilateral and unilateral vagotomy on gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine in wistar rats

✍ Scribed by Masaharu Tatsuta; Hiroyasu Iishi; Hisako Yamamura; Miyako Baba; Haruo Taniguchi

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: French
• Weight: 570 KB
• Volume: 42
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910420318

✦ Synopsis

After administration of N-methyl-N'-nitro-N-nitrosoguanidine for I5 weeks, the effects of bilateral, anterior and posterior vagotomy on the incidence, number and location of gastric adenocarcinomas, gastric acid secretion and cell proliferation of the gastric mucosa were investigated in inbred Wistar rats. Bilateral or anterior vagotomy, but not posterior vagotomy, significantly increased the incidence and number of adenocarcinomas at experimental week 52. In sham-operated control rats and rats subjected to bilateral vagotomy, there was no significant difference between the incidence or number of gastric tumors in the anterior and posterior walls. After anterior and posterior vagal denervation, however, there were significantly more gastric cancers on the denervated side than on the other. Bilateral and unilateral vagotomy resulted in significantly reduced gastric acid secretion by experimental weeks 25 and 52. Bilateral vagotomy significantly increased

MATERIAL AND METHODS

Animals

Young male inbred Wistar rats, about 6 weeks old, initially weighing 100 to 120 g, were obtained from Shizuoka Laboratory Animal Center (Shizuoka, Japan). The rats were housed in suspended, wire-bottomed, metabolic cages in animal quar-3T0 whom reprint requests should be sent.