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Studies of N-methyl-N′–nitro-N-nitrosoguanidine action on the guanylate cyclase-guanosine 3′5′ monophosphate system of isolated colonic epithelial cells

✍ Scribed by Frederick R. Derubertis; Patricia A. Craven; Reisuke Saito

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 861 KB
Volume: 45
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19800315)45:5+<1052::aid-cncr2820451304>3.0.co;2-c

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✍ Frederick R. de Rubertis; Patricia A. Craven 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 979 KB

The effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the guanylate cyclase (GC)-guanosine 3'5' monophosphate (cGMP) system of rat colonic mucosa were studied. MNNG (1 mM) increased colonic mucosal cGMP from 1.8 f 03 to 22.5 f 2.7 pmol/mg protein in 5 minutes. Increases in response to MNNG o