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Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines

✍ Scribed by Sakura Sakajiri; Takashi Kumagai; Norihiko Kawamata; Takayuki Saitoh; Jonathan W. Said; H. Phillip Koeffler


Book ID
113615866
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
382 KB
Volume
33
Category
Article
ISSN
0301-472X

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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th