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Proteomic profiling of human colon cancer cells treated with the histone deacetylase inhibitor belinostat

✍ Scribed by Hans Christian Beck; Jørgen Petersen; Søren Jensby Nielsen; Christian Morszeck; Peter B. Jensen; Maxwell Sehested; Morten Grauslund

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 222 KB
Volume: 31
Category: Article
ISSN: 0173-0835
DOI: 10.1002/elps.201000033

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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th