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Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis

✍ Scribed by Krämer, O H; Knauer, S K; Zimmermann, D; Stauber, R H; Heinzel, T

Book ID
110072667
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
408 KB
Volume
27
Category
Article
ISSN
0950-9232

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## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec