Increased frequency of TP53 mutations in
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Susan J. Ramus; Lynda G. Bobrow; Paul D.P. Pharoah; Damon S. Finnigan; Ami Fishm
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Article
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1999
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John Wiley and Sons
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English
โ 72 KB
๐ 2 views
We screened 81 ovarian tumours (30 BRCA1 associated, 18 BRCA2 associated, and 33 sporadic) for somatic TP53 mutations using both DNA analysis and immunostaining. TP53 mutations were significantly more frequent in tumours with mutations in BRCA1 (70% by immunostaining and 60% by DNA analysis) and BRC