Twenty-eight patients with histiocytosis X (HX) who had bone marrow aspirates andlor trephine biopsies taken at diagnosis were studied. Five of the 28 patients (18%) had bone marrow specimens with clusters of benign histiocytes characteristic of histiocytosis X. Several statistically significant cli
Histiocytosis X with involvement of brain
✍ Scribed by Joseph Rubé; Samuel de la Pava; John W. Pickren
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 923 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0008-543X
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📜 SIMILAR VOLUMES
Six children received etoposide as the single agent for treatment of Langerhans cell histiocytosis (LCH; histiocytosis X). Five were less than 2 years old at diagnosis. All had multiorgan involvement; one had liver and pulmonary dysfunction. Two infants also had clinical signs of immune deficiency.
A patient with systemic histiocytosis was treated with hemibody irradiation, vincristine, and prednisone. The patient died of an extensive peripheral neuropathy. An autopsy revealed gross histiocytosis-X involvement of the unirradiated tissues, and no evidence of disease within the field of irradiat
Viana et al. [I] described their experience with etoposide (VP-16) as initial therapy in the management of patients with Langerhans cell histiocytosis (LCH). However, caution should be used in advocating the use of an epipodophyllotoxin as the "drug of choice" for the treatment of this disorder. Alt