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Hindered rotation congeners of mazapertine: High affinity ligands for the 5-HT1A receptor

✍ Scribed by Ellen W. Baxter; Allen B. Reitz

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 293 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00074-7

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✦ Synopsis

Hindered rotation analogs of the antipsychotic mazapertine (1) were prepared. These compounds exhibited high affinity for the 5-HTl* receptor, but not for other serotonin or dopamine receptors. The related p carboline structures were also synthesized and were found to he potent .S-HT~A ligands. 0 1997

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