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Pd(0) Amination of Benzimidazoles as an Efficient Method towards New (Benzimidazolyl)piperazines with High Affinity for the 5-HT1A Receptor

✍ Scribed by Marı́a L López-Rodrı́guez; Bellinda Benhamú; David Ayala; J.Luis Rominguera; Marta Murcia; José A Ramos; Alma Viso

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 170 KB
Volume: 56
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(00)00225-8

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✦ Synopsis

AbstractÐNew (benzimidazolyl)amines have been synthesized from 4-and 6-bromobenzimidazole derivatives via palladium-mediated amination reactions. Among them, (benzimidazol-4(7)-yl)piperazine derivatives have been shown to be a new family of high af®nity 5-HT 1A receptor ligands.

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