Highly stereoselective synthesis of (2E,4E)-dienamides and (2E,4E)-dienoates via a double elimination reaction
β Scribed by Tadakatsu Mandai; Tadashi Moriyama; Koichiro Tsujimoto; Mikio Kawada; Junzo Otera
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 182 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
HIGHLY STEREOSELECTIVE SYNTHESIS OF (2E,4E)-DIENAMIDES AND (ZE,4E)-DIENOATES VIA A DOUBLE ELIMINATION REACTION
π SIMILAR VOLUMES
Di-n-butyl telluride, 2-bromoacetylisobutylamide (or 2-bromoacetylpiperidide) react directly with saturated or +unsaturated aldehydes at room temperature in the presence of potassium carbonate(s) to afford (2E)-, or (2E, 4E)-unsaturated carboxylic acid amides, respectively, in excellent yields with
2E, 4E )-Dienoic esters were synthesized stereoselectively from the corresponding 2-ynoic esters in high yield under the catalysis of an iridium hydride or ruthenium hydride complex. Recently, we reported the highly stereoselective