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Highly Enantioselective Cu-Catalyzed Asymmetric 1,4-Addition of Diphenylzinc to Cyclohexenone.

✍ Scribed by Diego Pena; Fernando Lopez; Syuzanna R. Harutyunyan; Adriaan J. Minnaard; Ben L. Feringa


Publisher
John Wiley and Sons
Year
2005
Weight
111 KB
Volume
36
Category
Article
ISSN
0931-7597

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Asymmetric 1,4-addition of phenylboronic
✍ Yoshiaki Takaya; Masamichi Ogasawara; Tamio Hayashi πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 84 KB πŸ‘ 2 views

Reaction of 2-cyclohexenone with phenylboronic acid in the presence of 3 mol% of a rhodium(I)/(S)-binap catalyst in dioxane/H2O (10/1) at 100 degrees C proceeded with high enantioselectivity to give a high yield of (S)-3-phenylcyclohexanone of up to 99% ee. The high enantioselectivity was achieved b