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Cu-Catalyzed Enantioselective 1,4-Additions of Aryl-Grignard Reagents to Cyclohexenone in the Presence of TADDOL-Derived Phosphane-Phosphite Ligands

✍ Scribed by Qaseem Naeemi; Mehmet Dindaroğlu; Darius P. Kranz; Janna Velder; Hans-Günther Schmalz


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
502 KB
Volume
2012
Category
Article
ISSN
1434-193X

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Enantioselective 1,4-Addition of Aliphat
✍ Dieter Seebach; Georg Jaeschke; Arkadius Pichota; Laurent Audergon 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 German ⚖ 268 KB

## Abstract Two simple thiols derived from the parent TADDOL, α,α,α′,α′ tetraphenyl‐2,2‐dimethyl‐1,3‐clioxolan‐4,5‐dimethanol, are used to prepare Cu^1^ complexes C and D to catalyze (0.05 equiv.) 1,4‐additions of __Grignard__ reagents RMgCl to cyclic enones with enantioselectivities which are comp