Highly enantioselective bioreduction of 2-fluorocinnamyl alcohols mediated by Saccharomyces cerevisiae

✍ Scribed by Fan Luo; Ping Wang; Yuefa Gong

• Book ID: 104097398
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 235 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.01.073

✦ Synopsis

Biocatalytic reduction of 2-fluorocinnamyl alcohols mediated by Saccharomyces cerevisiae was investigated in phosphate buffer solutions. Product analysis clearly showed that (S)-2-fluoro-3-arylpropanols were afforded in high yields with up to 92% ee value.