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Enantioselective reductions of ethyl 2-oxo-4-phenylbutyrate by Saccharomyces cerevisiae dehydrogenases

✍ Scribed by Iwona Kaluzna; Amy A. Andrew; Mariana Bonilla; Mark R. Martzen; Jon D. Stewart


Book ID
114395724
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
57 KB
Volume
17
Category
Article
ISSN
1381-1177

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## Abstract **BACKGROUND:** The enantioselectivity of reduction of ethyl 2‐oxo‐4‐phenylbutyrate (EOPB) to synthesize ethyl (__R__)‐2‐hydroxy‐4‐phenylbutyrate ((__R__)‐EHPB) catalyzed with baker's yeast in diethyl ether can be improved by the introduction of alpha‐phenacyl chloride (PC). However, th