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Asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate with baker's yeast in water/organic biphasic system

✍ Scribed by Yu-Gang Shi; Yun Fang; Hong-Ping Wu; Feng Li


Book ID
118473481
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
71 KB
Volume
136
Category
Article
ISSN
0168-1656

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## Abstract **BACKGROUND:** The enantioselectivity of reduction of ethyl 2‐oxo‐4‐phenylbutyrate (EOPB) to synthesize ethyl (__R__)‐2‐hydroxy‐4‐phenylbutyrate ((__R__)‐EHPB) catalyzed with baker's yeast in diethyl ether can be improved by the introduction of alpha‐phenacyl chloride (PC). However, th