Highly Efficient Asymmetric Three-Component Vinylogous Mannich Reaction Catalyzed by a Chiral Scandium(III)- N,N′-Dioxide Complex
✍ Scribed by Qi Zhang; Yonghai Hui; Xin Zhou; Lili Lin; Xiaohua Liu; Xiaoming Feng
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 174 KB
- Volume
- 352
- Category
- Article
- ISSN
- 1615-4150
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## Abstract **Mild‐mannered Mannich reaction**: Highly enantioselective one‐pot, three‐component Mannich‐type reaction of aldehydes, 2‐aminophenol, and ketene silyl acetal with 5 mol % of a __C__~__2__~‐symmetric __N__,__N__′‐dioxide‐based scandium(III) triflate (2:1) complex as the catalyst was ac
The catalytic conjugate addition of nitroalkanes to a,b-unsaturated ketones is one of the most important processes in organic synthesis, [1, 2, 3] since the corresponding products are very useful intermediates for the synthesis of a variety of more elaborate structures, such as amino alkanes, amino